Description

Ethyl 2-Phenyl-4-(2,2,2-Trifluoroethyl)-4,5-Dihydrooxazole-4-Carboxylate is a specialized heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique oxazoline scaffold, which is highly versatile for constructing complex molecular architectures, particularly in pharmaceutical research. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), agrochemicals, and other fine chemicals where the introduction of a trifluoroethyl-substituted oxazoline moiety is required.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the development of new drug candidates, particularly in central nervous system (CNS) and anti-infective therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Precursor: Serves as a precursor for chiral oxazoline ligands, which are crucial in asymmetric catalysis for producing enantiomerically pure compounds.
• Material Science Research: Employed in the synthesis of novel organic frameworks and functional materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms and biological pathways.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses serving the pharmaceutical and biotechnology industries.

Basic Information

Product Name	Ethyl 2-Phenyl-4-(2,2,2-Trifluoroethyl)-4,5-Dihydrooxazole-4-Carboxylate
CAS No.	1126530-82-2
Molecular Formula	C14H14F3NO3
Molecular Weight	301.26 g/mol
Synonyms	4,5-Dihydro-2-phenyl-4-[(2,2,2-trifluoroethyl)oxazole]-4-carboxylic acid ethyl ester; Ethyl 4,5-dihydro-2-phenyl-4-(2,2,2-trifluoroethyl)oxazole-4-carboxylate; 2-Phenyl-4-(2,2,2-trifluoroethyl)-4,5-dihydrooxazole-4-carboxylic acid ethyl ester; 4-Carbethoxy-2-phenyl-4-(2,2,2-trifluoroethyl)-4,5-dihydrooxazole; Oxazole-4-carboxylic acid, 4,5-dihydro-2-phenyl-4-(2,2,2-trifluoroethyl)-, ethyl ester; Trifluoroethyl oxazoline carboxylate derivative
EINECS	Contact for details

Quality Control

Our Ethyl 2-Phenyl-4-(2,2,2-Trifluoroethyl)-4,5-Dihydrooxazole-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC for residual solvent analysis, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.