Description

4,4,5,5-Tetramethyl-2-(3-Methyl-4-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane is a high-purity, synthetically valuable organoboron reagent. This compound serves as a critical building block in modern cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides that incorporate trifluoromethylphenyl motifs for enhanced efficacy.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands and organometallic catalysts.
• Chemical Biology Probes: Utilized in the synthesis of boron-containing probes for bioimaging and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(3-Methyl-4-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane
CAS No.	1126479-89-7
Molecular Formula	C14H18BF3O2
Molecular Weight	286.10 g/mol
Synonyms	2-(3-Methyl-4-(trifluoromethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (3-Methyl-4-(trifluoromethyl)phenyl)boronic acid pinacol ester; 3-Methyl-4-(trifluoromethyl)benzeneboronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[3-methyl-4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolane; Pinacol [3-methyl-4-(trifluoromethyl)phenyl]boronate; 3-Methyl-4-trifluoromethylphenylboronic acid pinacol ester; CAS 1126479-89-7
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(3-Methyl-4-(Trifluoromethyl)Phenyl)-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including NMR, HPLC, and GC analysis, to ensure high chemical purity and consistent performance in sensitive synthetic applications. Certificates of Analysis (COA) with full traceability are provided for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to maintain stability and prevent moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.