Description

3-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(Triisopropylsilyl)-1H-Pyrrole is a highly versatile and valuable organoboron building block, specifically designed for advanced cross-coupling reactions. Its core value lies in enabling the precise and efficient construction of complex heterocyclic molecules, which are critical scaffolds in modern pharmaceutical and agrochemical discovery. This compound is essential for research chemists and process development scientists working in medicinal chemistry, materials science, and the synthesis of novel electronic materials.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: As a key boronic ester reagent for constructing complex pyrrole-containing architectures.
• Pharmaceutical Intermediate: Synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing functionalized pyrrole or indole cores.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides that require specific heterocyclic motifs.
• Materials Science Research: Precursor for organic semiconductors, conductive polymers, and advanced organic electronic materials.
• Chemical Biology Probes: Used in the development of molecular probes and labeled compounds for biological target identification.
• Process Chemistry & Scale-up: Enables the transition from laboratory-scale discovery to pilot and commercial-scale manufacturing of fine chemicals.

Basic Information

Product Name	3-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(Triisopropylsilyl)-1H-Pyrrole
CAS No.	1126425-82-8
Molecular Formula	C21H39BClNO2Si
Molecular Weight	411.89 g/mol
Synonyms	1-(Triisopropylsilyl)-3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole; 3-Chloro-1-(triisopropylsilyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole; TIPS-Protected Chloropyrrole Boronic Ester; 1H-Pyrrole, 3-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-[tris(1-methylethyl)silyl]-; 3-Chloro-4-(pinacolatoboryl)-1-(triisopropylsilyl)pyrrole
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1-(Triisopropylsilyl)-1H-Pyrrole adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot undergoes comprehensive analytical characterization, including NMR (¹H, ¹³C, ¹¹B) and HPLC purity analysis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term stability, it is recommended to store under an inert atmosphere (argon or nitrogen) at temperatures between 2°C and 8°C. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
¹H NMR	Conforms to structure
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.