Description

1-[3-Chloro-5-Trifluoromethylphenyl]-2,2,2-Trifluoroethanone is a high-value fluorinated aromatic ketone building block. This compound is critical for the synthesis of advanced molecules due to its unique trifluoromethyl and trifluoroacetyl functional groups, which impart desirable properties like metabolic stability and lipophilicity. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals that require fluorinated aromatic segments for thermal and chemical stability.
• Organic Synthesis Reagent: Employed in cross-coupling reactions and as a precursor for heterocyclic compounds in academic and industrial research laboratories.
• Fluorine Chemistry Research: Essential for studying structure-activity relationships (SAR) and developing new fluorination methodologies.

Basic Information

Product Name	1-[3-Chloro-5-Trifluoromethylphenyl]-2,2,2-Trifluoroethanone
CAS No.	1125812-58-9
Molecular Formula	C9H3ClF6O
Molecular Weight	276.56 g/mol
Synonyms	3'-Chloro-5'-(trifluoromethyl)trifluoroacetophenone; 2,2,2-Trifluoro-1-[3-chloro-5-(trifluoromethyl)phenyl]ethanone; 1-(3-Chloro-5-trifluoromethylphenyl)-2,2,2-trifluoroethanone; 3-Chloro-α,α,α-trifluoro-5-(trifluoromethyl)acetophenone; 3-Chloro-5-(trifluoromethyl)phenyl trifluoromethyl ketone; (3-Chloro-5-trifluoromethylphenyl)trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our 1-[3-Chloro-5-Trifluoromethylphenyl]-2,2,2-Trifluoroethanone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.