Description

3-Chloro-4-(Difluoromethoxy)Benzaldehyde is a high-purity, specialized aromatic aldehyde building block of significant importance in advanced organic synthesis. Its core value lies in its unique molecular structure, which incorporates both chloro and difluoromethoxy substituents, enabling the precise construction of complex molecules with tailored properties. This compound is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for developing new active ingredients, as well as by fine chemical manufacturers producing advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and inflammation.
• Agrochemical Synthesis: Serves as a critical building block for developing new-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance bioavailability and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Used in the research and production of advanced electronic materials, including liquid crystal displays (LCDs) and organic light-emitting diodes (OLEDs), due to its aromatic core and halogenated structure.
• Fine Chemical Manufacturing: Employed as a versatile intermediate for synthesizing more complex benzaldehyde derivatives, dyes, and functional polymers.
• Cross-Coupling Reactions: The aldehyde and halogen functionalities make it a suitable substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to create biaryl structures.

Basic Information

Product Name	3-Chloro-4-(Difluoromethoxy)Benzaldehyde
CAS No.	1121585-21-4
Molecular Formula	C8H5ClF2O2
Molecular Weight	206.57 g/mol
Synonyms	3-Chloro-4-(difluoromethoxy)benzaldehyde; 4-(Difluoromethoxy)-3-chlorobenzaldehyde; Benzaldehyde, 3-chloro-4-(difluoromethoxy)-; 3-Chloro-4-difluoromethoxybenzaldehyde
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-(Difluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its property of being easily oxidized, it is recommended to store under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.