Description

tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydropyridine-1(2H)-Carboxylate is a high-value, protected boronic ester derivative crucial for modern synthetic chemistry. This compound serves as a key synthetic intermediate, enabling the construction of complex molecules through efficient cross-coupling reactions. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Serves as a versatile handle for bioconjugation and the synthesis of molecular probes for target identification.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry.
• Process Chemistry & Scale-up: Provides a reliable and scalable route for introducing the dihydropyridine-boronate moiety in pilot plant and manufacturing settings.

Basic Information

Item	Detail
Product Name	tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydropyridine-1(2H)-Carboxylate
CAS No.	1121057-77-9
Molecular Formula	C16H28BNO4
Molecular Weight	309.21 g/mol
Synonyms	1-Boc-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine; tert-Butyl 5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine-1-carboxylate; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester; 1-N-Boc-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,2,3,4-tetrahydropyridine; 5-(Pinacolatoboryl)-1,2,3,4-tetrahydropyridine-1-carboxylic acid tert-butyl ester; 1,2,3,4-Tetrahydro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-3,4-Dihydropyridine-1(2H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the material under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain optimal stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.