Description

n-(2,2,2-Trifluoroethyl)Cyclobutanamine is a specialized fluorinated amine building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the cyclobutane ring's conformational rigidity and the strong electron-withdrawing properties of the trifluoroethyl group, enabling precise modulation of molecular properties. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, metabolic diseases, and oncology.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms can enhance bioavailability, metabolic stability, and binding affinity.
• Ligand & Catalyst Development: Serves as a precursor for chiral ligands or organocatalysts in asymmetric synthesis, leveraging the cyclobutane scaffold for steric control.
• Material Science Precursor: Employed in the synthesis of fluorinated polymers or advanced materials with specific surface properties, thermal stability, or chemical resistance.
• Chemical Biology Probe: Useful for incorporating a fluorinated, conformationally constrained amine moiety into probes for studying enzyme mechanisms or protein-ligand interactions.

Basic Information

Product Name	n-(2,2,2-Trifluoroethyl)Cyclobutanamine
CAS No.	1116744-54-7
Molecular Formula	C6H10F3N
Molecular Weight	153.15 g/mol
Synonyms	N-(2,2,2-Trifluoroethyl)cyclobutanamine; 2,2,2-Trifluoro-N-cyclobutylethanamine; Cyclobutanamine, N-(2,2,2-trifluoroethyl)-; 1-(2,2,2-Trifluoroethyl)cyclobutanamine; 1116744-54-7; N-Cyclobutyl-2,2,2-trifluoroethanamine
EINECS	Contact for details

Quality Control

Our n-(2,2,2-Trifluoroethyl)Cyclobutanamine is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity, essential for sensitive R&D and scale-up processes. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and GC-MS. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.