Description

2-(4,5-Dichloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, particularly for developing active pharmaceutical ingredients (APIs) and functional organic molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those containing complex biaryl or heterobiaryl structures.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides with improved efficacy and selectivity.
• Material Science Research: Building block for organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers.
• Suzuki-Miyaura Cross-Coupling: A versatile reagent for palladium-catalyzed coupling reactions to form biaryl bonds under mild conditions.
• Chemical Biology Probes: Enables the labeling and study of biological targets and pathways.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects.

Basic Information

Product Name	2-(4,5-Dichloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1116681-96-9
Molecular Formula	C12H14BCl2FO2
Molecular Weight	291.96 g/mol
Synonyms	4,5-Dichloro-2-fluorophenylboronic acid pinacol ester; (4,5-Dichloro-2-fluorophenyl)boronic acid pinacol ester; 2-(4,5-Dichloro-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4,5-Dichloro-2-fluoro-1-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzene; (4,5-Dichloro-2-fluorophenyl)BPin; CAS 1116681-96-9; Pinacol (4,5-dichloro-2-fluorophenyl)boronate
EINECS	Contact for details

Quality Control

Our 2-(4,5-Dichloro-2-Fluorophenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC analysis, to ensure high purity and batch-to-batch consistency suitable for sensitive coupling reactions. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.