Description

n-[2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl]-4-Fluorobenzenesulfonamide is a high-purity, synthetically valuable boronic ester derivative designed for advanced pharmaceutical research and development. This compound serves as a critical building block in modern medicinal chemistry, enabling the formation of carbon-carbon bonds via Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by pharmaceutical R&D teams and contract research organizations (CROs) for the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for oncology, neurology, and anti-inflammatory therapies.
• Suzuki-Miyaura Cross-Coupling: Essential building block for constructing biaryl and heterobiaryl structures central to many modern drug molecules.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates.
• Chemical Biology Probes: Enables the creation of tagged molecules for studying biological pathways and target engagement.
• Library Synthesis: Employed in the parallel and combinatorial synthesis of diverse compound libraries for high-throughput screening.
• Process Chemistry Development: Serves as a starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	n-[2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl]-4-Fluorobenzenesulfonamide
CAS No.	1112983-31-9
Molecular Formula	C₁₇H₁₉BClFN₂O₄S
Molecular Weight	412.67 g/mol
Synonyms	4-Fluoro-N-[2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]benzenesulfonamide; 2-Chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(4-fluorophenylsulfonyl)pyridin-3-amine; 1112983-31-9; 4-Fluoro-N-(2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)benzenesulfonamide; Boronic ester pyridine sulfonamide derivative; 3-((4-Fluorophenyl)sulfonamido)-2-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
EINECS	Contact for details

Quality Control

Our n-[2-Chloro-5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Pyridin-3-Yl]-4-Fluorobenzenesulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring full traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.