Description

3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Benzaldehyde is a high-purity, advanced pharmaceutical intermediate and versatile organic building block. This compound is valued for its unique molecular architecture, combining a pinacol boronate ester group with a trifluoromethoxy-substituted benzaldehyde, enabling precise cross-coupling reactions and functional group transformations. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the synthesis of novel active ingredients and complex molecules.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key boronic ester precursor for constructing biaryl and heterobiaryl scaffolds prevalent in drug discovery.
• Pharmaceutical Intermediate: Critical building block in the synthesis of potential active pharmaceutical ingredients (APIs), especially those targeting CNS disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides leveraging the trifluoromethoxy group for enhanced bioactivity and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced organic electronic materials and liquid crystals.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules due to the reactivity of the aldehyde and boronate groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of tailored compounds for client-specific research programs.

Basic Information

Product Name	3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Benzaldehyde
CAS No.	1112209-48-9
Molecular Formula	C14H16BF3O4
Molecular Weight	316.08 g/mol
Synonyms	5-(Trifluoromethoxy)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde; 3-Formyl-5-(trifluoromethoxy)phenylboronic acid pinacol ester; [5-(Trifluoromethoxy)-1,3-phenylene]bis(pinacolboronate) derivative; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(trifluoromethoxy)benzenecarbaldehyde; 5-(Trifluoromethoxy)-3-(pinacolatoboryl)benzaldehyde; 3-Borono-5-(trifluoromethoxy)benzaldehyde pinacol ester; 3-(Pinacolboronato)-5-(trifluoromethoxy)benzaldehyde
EINECS	Contact for details

Quality Control

Our 3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-5-(Trifluoromethoxy)Benzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) with detailed chromatographic data are provided for traceability and to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed in a dry inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.