Description

Imidazo[1,2-A]Pyrimidine, 2,3-Dimethyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)- is a high-value, organoboron building block essential for modern synthetic chemistry. This compound matters for its role as a key intermediate in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drug candidates containing imidazopyrimidine or complex heterocyclic cores.
• Agrochemical Synthesis: Used to construct novel fungicides, herbicides, and insecticides by introducing the boronate ester functional group for carbon-carbon bond formation.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport materials.
• Cross-Coupling Reactions: Specifically designed for use in palladium-catalyzed Suzuki-Miyaura cross-couplings to attach the imidazopyrimidine moiety to (hetero)aryl or vinyl halides.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and labeled compounds for biochemical and diagnostic research applications.
• Library Synthesis for Drug Discovery: Enables the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in medicinal chemistry programs.

Basic Information

Product Name	Imidazo[1,2-A]Pyrimidine, 2,3-Dimethyl-6-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-
CAS No.	1111638-08-4
Molecular Formula	C14H22BN3O2
Molecular Weight	275.16 g/mol
Synonyms	2,3-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)imidazo[1,2-a]pyrimidine; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dimethylimidazo[1,2-a]pyrimidine; 2,3-Dimethylimidazo[1,2-a]pyrimidine-6-boronic acid pinacol ester; Imidazo[1,2-a]pyrimidine-6-boronic acid, 2,3-dimethyl-, pinacol ester; 2,3-Dimethyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-imidazo[1,2-a]pyrimidine; B-(2,3-Dimethylimidazo[1,2-a]pyrimidin-6-yl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our Imidazo[1,2-A]Pyrimidine boronic ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and at a controlled room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.