Description

3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-5-Boronic Acid Pinacol Ester is a high-purity, heterocyclic boronic ester building block essential for modern synthetic chemistry. This compound matters because it serves as a critical intermediate in the Suzuki-Miyaura cross-coupling reaction, enabling the efficient formation of carbon-carbon bonds under mild conditions. Pharmaceutical, agrochemical, and advanced materials researchers need it for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and functional organic materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides requiring specific heterocyclic scaffolds.
• Material Science: Employed in the creation of organic electronic materials, such as OLED (Organic Light-Emitting Diode) emitters and charge transport layers.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and inhibitors.
• Catalyst & Ligand Development: Serves as a precursor for creating novel ligands and catalysts used in asymmetric synthesis.
• Academic & Contract Research: A valuable reagent for methodology development and exploring new cross-coupling pathways in academic and industrial R&D labs.

Basic Information

Product Name	3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-5-Boronic Acid Pinacol Ester
CAS No.	1111637-76-3
Molecular Formula	C13H18BN3O2
Molecular Weight	259.11 g/mol
Synonyms	3-Methyl-1H-pyrazolo[3,4-b]pyridin-5-ylboronic acid pinacol ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-methyl-1H-pyrazolo[3,4-b]pyridine; 3-Methyl-1H-pyrazolo[3,4-b]pyridine-5-boronic acid pinacol ester; 3-Methyl-1H-pyrazolo[3,4-b]pyridin-5-ylboronic acid, pinacol ester; 1H-Pyrazolo[3,4-b]pyridine-5-boronic acid, 3-methyl-, pinacol ester; 3-Methyl-1H-pyrazolo[3,4-b]pyridine-5-boronate pinacol ester; Boronic acid, B-(3-methyl-1H-pyrazolo[3,4-b]pyridin-5-yl)-, pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Methyl-1H-Pyrazolo[3,4-B]Pyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural integrity. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.