Description

Methyl 5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-2-Carboxylate is a high-value organoboron building block, specifically a thiophene boronic ester, designed for advanced synthetic chemistry. This compound is critical for enabling Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules with precision. It is an essential raw material for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science sectors who require reliable, high-purity intermediates for drug discovery and functional material development.

Application

This versatile boronic ester is a key synthon in modern organic synthesis, primarily used to introduce functionalized thiophene moieties into target molecules.

• Pharmaceutical Intermediate: Core building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides with tailored properties.
• Organic Electronic Materials: Critical precursor for constructing conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Ligand and Catalyst Development: Serves as a starting material for creating novel ligands and complex molecules used in catalysis.
• Chemical Research & Development: Enables academic and industrial R&D for exploring new chemical spaces and reaction methodologies via cross-coupling.
• Liquid Crystal and Advanced Material Synthesis: Used to create functionalized thiophene derivatives for specialty materials.

Basic Information

Product Name	Methyl 5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-2-Carboxylate
CAS No.	1109284-49-2
Molecular Formula	C13H19BO4S
Molecular Weight	282.16 g/mol
Synonyms	5-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylic acid methyl ester; Methyl 5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene-2-carboxylate; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-methylthiophene-2-carboxylic acid methyl ester; 2-Thiophenecarboxylic acid, 5-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, methyl ester; 5-Methyl-4-(pinacolatoboron)thiophene-2-carboxylic acid methyl ester; Methyl 5-methyl-4-(pinacolatoboron)thiophene-2-carboxylate; Thiophene-2-boronic acid pinacol ester derivative
EINECS	Contact for details

Quality Control

Our production of Methyl 5-Methyl-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Thiophene-2-Carboxylate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR (1H and 13C), and GC/MS, to verify identity, purity, and the absence of critical impurities. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring full traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.