Description

5-(4-Fluorophenyl)Pyridine-3-Boronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative, widely recognized by its CAS number 1105663-88-4. This compound serves as a crucial Suzuki-Miyaura cross-coupling reagent, enabling the efficient construction of complex biaryl structures essential for advanced material and pharmaceutical development. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those containing fluorinated biphenyl or heterobiaryl motifs for oncology, CNS, and antiviral therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorophenylpyridine scaffold can impart desirable biological activity and metabolic stability.
• Material Science & OLED Development: Employed in the creation of organic light-emitting diode (OLED) materials, liquid crystals, and other advanced organic electronic components requiring precise molecular architecture.
• Chemical Biology & Probe Development: Acts as a versatile handle for bioconjugation and the synthesis of molecular probes for target identification and validation in drug discovery.
• Academic & Contract Research: A staple reagent in academic laboratories and CROs (Contract Research Organizations) for methodology development and the exploration of new chemical space.
• Scale-up & Process Chemistry: Suitable for use in kilogram-scale pilot plant and manufacturing processes under optimized Suzuki-Miyaura cross-coupling conditions.

Basic Information

Product Name	5-(4-Fluorophenyl)Pyridine-3-Boronic Acid Pinacol Ester
CAS No.	1105663-88-4
Molecular Formula	C₁₇H₁₉BFNO₂
Molecular Weight	299.15 g/mol
Synonyms	5-(4-Fluorophenyl)-3-pyridineboronic acid pinacol ester; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-5-(4-fluorophenyl)pyridine; [5-(4-Fluorophenyl)pyridin-3-yl]boronic acid pinacol ester; 5-(4-Fluorophenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-(p-Fluorophenyl)pyridine-3-boronic acid pinacol ester; Boronic acid, B-[5-(4-fluorophenyl)-3-pyridinyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 5-(4-Fluorophenyl)Pyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications requiring reproducible results in sensitive synthetic sequences, from early-stage research to cGMP-compliant production.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (argon or nitrogen) when opening the container for use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.