Description

2-(Benzofuran-2-Yl)-6-Methyl-1,3,6,2-Dioxazaborocane-4,8-Dione, 2-Benzofuranboronic Acid Mida Ester is a specialized, high-purity boronic acid derivative protected as a stable MIDA (N-methyliminodiacetic acid) ester. This advanced synthetic intermediate is critical for enabling complex cross-coupling reactions, particularly in multi-step synthesis where traditional boronic acids may be unstable. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the efficient and reliable construction of complex molecules, including active pharmaceutical ingredients (APIs) and agrochemicals.

Application

• Pharmaceutical Intermediate: A key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates and complex heterocyclic compounds.
• Agrochemical Synthesis: Used in the research and development of advanced crop protection agents and herbicides.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs and OFETs.
• Chemical Biology & Probe Development: Serves as a stable precursor for creating bioconjugates and molecular probes for diagnostic applications.
• Process Chemistry & Scale-up: Valued for its enhanced stability and handling properties compared to free boronic acids, facilitating robust manufacturing processes.
• Academic & Contract Research: A vital reagent for methodological development in organic synthesis and catalysis research.

Basic Information

Product Name	2-(Benzofuran-2-Yl)-6-Methyl-1,3,6,2-Dioxazaborocane-4,8-Dione, 2-Benzofuranboronic Acid Mida Ester
CAS No.	1104637-65-1
Molecular Formula	C14H12BNO5
Molecular Weight	285.06 g/mol
Synonyms	2-(Benzofuran-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione; Benzofuran-2-ylboronic acid MIDA ester; 2-(Benzofuran-2-yl)-6-methyl-[1,3,6,2]dioxazaborocane-4,8-dione; 2-Benzofuranboronic Acid N-Methyliminodiacetic Acid (MIDA) Ester; 2-(2-Benzofuranyl)-6-methyl-4,8-dioxo-1,3,6,2-dioxazaborocane; Boronic acid, B-(2-benzofuranyl)-, (OC-6-11)-, cyclic ester with N-methyliminodiacetic acid; MIDA Boronate of Benzofuran-2-boronic Acid
EINECS	Contact for details

Quality Control

Our 2-Benzofuranboronic Acid Mida Ester is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for demanding synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP-compliant production for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the original container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.