Description

2-Pyridinylboronic Acid Mida Ester is a protected boronic acid derivative, specifically a N-methyliminodiacetic acid (MIDA) ester, designed for enhanced stability and controlled reactivity in complex synthetic sequences. This compound is a critical building block in modern cross-coupling chemistry, offering superior shelf-life and handling characteristics compared to its free boronic acid counterpart. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the efficient synthesis of complex heterocyclic targets and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heterobiaryl scaffolds prevalent in drug discovery.
• Agrochemical Development: Used in the synthesis of novel pesticides and herbicides containing pyridine motifs.
• Material Science Research: Serves as a building block for creating organic electronic materials and metal-organic frameworks (MOFs) with tailored properties.
• Process Chemistry & Scale-up: Its stability makes it ideal for multi-step synthesis and large-scale manufacturing processes requiring robust, air-stable intermediates.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries for biological activity screening.
• Ligand and Catalyst Preparation: Used in the synthesis of specialized ligands for catalysis and coordination chemistry.

Basic Information

Product Name	2-Pyridinylboronic Acid Mida Ester
CAS No.	1104637-58-2
Molecular Formula	C11H13BN2O4
Molecular Weight	248.05 g/mol
Synonyms	2-Pyridylboronic Acid MIDA Ester; (2-Pyridinyl)-N-methyliminodiacetic acid boronate; 2-Pyridineboronic Acid MIDA Ester; 2-Pyridyl MIDA Boronate; B-(2-Pyridinyl)-N-methyliminodiacetic acid boronate; 2-Pyridinylboronic Acid coupled with N-Methyliminodiacetic Acid; MIDA Boronate of 2-Pyridineboronic Acid
EINECS	Contact for details

Quality Control

Our 2-Pyridinylboronic Acid Mida Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure compliance with high-purity research and development standards. Comprehensive Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.