Description

Propynylboronic Acid Mida Ester is a specialized organoboron reagent where the boronic acid functionality is protected as a stable N-methyliminodiacetic acid (MIDA) ester. This protection strategy is critical for enabling complex, iterative cross-coupling reactions, particularly in automated synthesis and the construction of sensitive molecular architectures. It is an essential building block for research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, air- and moisture-stable boron reagents for sophisticated synthetic routes.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent in Suzuki-Miyaura cross-coupling reactions for constructing carbon-carbon bonds in active pharmaceutical ingredients (APIs) and drug candidates.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides that require the incorporation of an alkyne-substituted boron moiety.
• Materials Science: Serves as a precursor for creating conjugated polymers and organic electronic materials where the propynyl group is integral to the material's properties.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and bioconjugates, leveraging the stability of the MIDA boronate for sequential functionalization.
• Process Chemistry & Scale-up: Valued for its enhanced stability over the corresponding boronic acid, facilitating handling, storage, and use in multi-step manufacturing processes.
• Academic & Industrial R&D: A fundamental tool for methodological development in organic synthesis, enabling new catalytic transformations and library synthesis.

Basic Information

Product Name	Propynylboronic Acid Mida Ester
CAS No.	1104637-55-9
Molecular Formula	C10H14BNO4
Molecular Weight	223.04 g/mol
Synonyms	1-Propyn-1-ylboronic Acid MIDA Ester; (1-Propynyl)boronic Acid MIDA Ester; N-Methyliminodiacetic Acid (1-Propynyl)boronate; Prop-1-yn-1-ylboronic Acid MIDA Ester; MIDA Propynylboronate; Propynyl MIDA Boronate; 2-[(1-Propynyl)hydroxyboranyl]-N-methyl-acetamidoacetic Acid
EINECS	Contact for details

Quality Control

Every batch of Propynylboronic Acid Mida Ester is manufactured and tested under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for identity, purity, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and may benefit from storage under an inert atmosphere for long-term preservation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.