Description

trans-1-Propenylboronic Acid Mida Ester is a high-purity, advanced synthetic intermediate featuring the N-methyliminodiacetic acid (MIDA) protecting group. This compound is specifically engineered to enhance the stability and handling of the reactive boronic acid moiety, enabling more efficient and reliable cross-coupling reactions. It is an essential building block for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require precise control over stereochemistry and functional group compatibility in their synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions, particularly for introducing the trans-propenyl moiety.
• Agrochemical Synthesis: Used in creating novel crop protection agents and herbicides that require specific alkene geometries for optimal biological activity.
• Materials Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers and organic electronic materials.
• Chemical Biology & Probe Development: Employed in the construction of molecular probes and bioconjugates where the MIDA boronate's stability under physiological conditions is advantageous.
• Process Chemistry & Scale-up: The MIDA protecting group facilitates safer handling and purification in multi-step industrial synthesis compared to its unprotected boronic acid counterpart.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	trans-1-Propenylboronic Acid Mida Ester
CAS No.	1104637-46-8
Molecular Formula	C9H14BNO4
Molecular Weight	211.02 g/mol
Synonyms	(E)-1-Propenylboronic Acid MIDA Ester; (E)-1-Propenyl-MIDA-boronate; trans-1-Propenyl-MIDA-boronate; N-Methyliminodiacetic Acid (E)-1-Propenylboronate; trans-Propenylboronic Acid N-Methyliminodiacetic Acid Ester; MIDA trans-1-Propenylboronate; B-(1E)-1-Propen-1-yl-2,2'-(methylazanediyl)diacetateboron; trans-Vinylboronic Acid MIDA Ester (homolog)
EINECS	Contact for details

Quality Control

Our trans-1-Propenylboronic Acid Mida Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and mass spectrometry, to ensure high chemical purity and isomeric integrity. Certificates of Analysis (COA) with full characterization data are provided to guarantee compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Isomeric Purity (trans)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.