Description

n-Butylboronic Acid Mida Ester is a specialized, protected boronic acid derivative designed for enhanced stability and controlled reactivity in advanced synthetic chemistry. This compound is a critical reagent in modern cross-coupling methodologies, offering superior handling characteristics compared to its free boronic acid counterpart. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the efficient and reliable construction of complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant coupling partner for the synthesis of biaryl and heterobiaryl compounds, key scaffolds in active pharmaceutical ingredients (APIs).
• Pharmaceutical Intermediate Synthesis: Used in the multi-step synthesis of drug candidates, where the MIDA (N-methyliminodiacetic acid) protecting group allows for sequential, chemoselective cross-coupling steps.
• Agrochemical Research & Development: Employed in creating novel herbicides, fungicides, and insecticides that require specific aryl-alkyl linkages.
• Material Science & OLED Development: Facilitates the synthesis of conjugated organic molecules and ligands for electronic materials and light-emitting devices.
• Academic & Process Chemistry: A valuable tool in methodological development and scalable route design due to its crystallinity and bench stability.

Basic Information

Item	Details
Product Name	n-Butylboronic Acid Mida Ester
CAS No.	1104637-43-5
Molecular Formula	C11H20BNO4
Molecular Weight	241.09 g/mol
Synonyms	Butylboronic Acid MIDA Ester; N-Methyliminodiacetic Acid Butylboronate; Butyl-B(MIDA); 1-Butyl-5,5-dimethyl-1,3,2-dioxaborinane-4,6-dione (incorrect but common misnomer); Butylboronic Acid coupled with N-Methyliminodiacetic Acid; B-Butylboronic Acid MIDA Ester; MIDA Butylboronate; (Butylboronic acid)-N-methyliminodiacetic acid complex
EINECS	Contact for details

Quality Control

Every batch of n-Butylboronic Acid Mida Ester is manufactured under strict quality management protocols. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity (typically by 1H/11B/13C NMR and HPLC), identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity. Recommended storage temperature: 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Purity (NMR)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.