Description

Methylboronic Acid Mida Ester is a specialized organoboron reagent, specifically a methylboronic acid derivative protected with the N-methyliminodiacetic acid (MIDA) ligand. This compound is critically important in modern synthetic chemistry, particularly for Suzuki-Miyaura cross-coupling reactions, where it offers superior stability and controlled reactivity compared to its boronic acid counterpart. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the precise construction of complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for the controlled introduction of methyl groups in drug discovery and development, enabling the synthesis of complex active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in creating novel pesticide and herbicide candidates by facilitating efficient carbon-carbon bond formation.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air- and moisture-tolerant methyl transfer reagent in palladium-catalyzed couplings, offering improved handling and shelf-life.
• Materials Science: Employed in the synthesis of organic electronic materials, such as polymers and small molecules for OLEDs or OFETs, where precise structural control is required.
• Chemical Biology & Proteomics: Utilized as a tool compound for bioconjugation or as a precursor in the synthesis of molecular probes.
• Process Chemistry & Scale-up: Its enhanced stability makes it suitable for optimizing and scaling up synthetic routes from laboratory to pilot plant and manufacturing scales.

Basic Information

Product Name	Methylboronic Acid Mida Ester
CAS No.	1104637-40-2
Molecular Formula	C7H12BNO4
Molecular Weight	184.99 g/mol
Synonyms	Methylboronic Acid MIDA Ester; Methyl MIDA Boronate; (Methylboronic acid)-N-methyliminodiacetic acid ester; B-Methyl-N-methyliminodiacetic acid boronate; MIDA Methylboronate; Methylboronic Acid coupled with N-Methyliminodiacetic Acid; CAS 1104637-40-2
EINECS	Contact for details

Quality Control

Our Methylboronic Acid Mida Ester is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR (1H, 11B, 13C) and HPLC analysis, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
1H NMR	Conforms to structure
11B NMR	Conforms to structure
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.