Description

Cyclobutylboronic Acid Mida Ester is a specialized organoboron reagent where the boronic acid functionality is protected by the N-methyliminodiacetic acid (MIDA) group. This protection is crucial for enhancing stability and enabling controlled, iterative cross-coupling reactions in complex synthesis. It is an essential building block for medicinal chemists and process R&D scientists developing novel pharmaceutical compounds, agrochemicals, and advanced materials. The MIDA ester form offers superior handling characteristics and shelf-life compared to its free boronic acid counterpart.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for the palladium-catalyzed formation of carbon-carbon bonds, introducing the cyclobutyl moiety into complex molecular architectures.
• Pharmaceutical Intermediate Synthesis: Used in the research and development of active pharmaceutical ingredients (APIs), particularly for constructing strained, bioactive ring systems.
• Agrochemical Research: Serves as a building block for creating novel herbicides, fungicides, and insecticides with unique steric and electronic properties.
• Material Science: Employed in the synthesis of organic electronic materials, ligands for catalysis, and other functional polymers.
• Iterative Synthesis: The MIDA protecting group allows for the sequential introduction of multiple boronic acid derivatives in one-pot or automated synthesis platforms.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries featuring the metabolically stable cyclobutyl ring for high-throughput screening.

Basic Information

Item	Details
Product Name	Cyclobutylboronic Acid Mida Ester
CAS No.	1104637-37-7
Molecular Formula	C11H18BNO4
Molecular Weight	239.08 g/mol
Synonyms	Cyclobutylboronic Acid MIDA Ester; Cyclobutyl-MIDA-boronate; N-Methyliminodiacetic Acid Cyclobutylboronate; (Cyclobutyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane? (Common pinacol ester, included for search relevance); Cyclobutylboronic Acid coupled with MIDA; B-Cyclobutyl-N-methyliminodiacetic acid boronate ester; MIDA Cyclobutylboronate; Cyclobutyl-B(MIDA)
EINECS	Contact for details

Quality Control

Every batch of Cyclobutylboronic Acid Mida Ester is manufactured under strict quality management systems. We employ advanced analytical techniques including NMR (¹H, ¹³C, ¹¹B), HPLC, and LC-MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term stability and to prevent hydrolysis. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.