Description

3-Bromobenzothiophene-2-Boronic Acid Mida Ester is a high-value, advanced synthetic intermediate designed for complex cross-coupling reactions. This compound matters because the Mida (N-methyliminodiacetic acid) ester group provides exceptional stability and controlled reactivity, offering significant advantages over traditional boronic acids or esters in multi-step syntheses. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel benzothiophene-based scaffolds in drug discovery and active ingredient development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting various therapeutic areas.
• Agrochemical Research: Used to create novel benzothiophene-containing compounds for the development of new herbicides, fungicides, and insecticides.
• Material Science: Serves as a precursor for organic electronic materials, such as organic semiconductors and light-emitting materials.
• Suzuki-Miyaura Cross-Coupling: Enables the controlled, sequential introduction of aryl groups in complex molecule assembly due to its stabilized boronate form.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological processes and target engagement.
• Academic & Contract Research: Essential for methodological development and library synthesis in academic and contract research organizations (CROs).

Basic Information

Product Name	3-Bromobenzothiophene-2-Boronic Acid Mida Ester
CAS No.	1104636-80-7
Molecular Formula	C₁₃H₁₁BBrNO₄S
Molecular Weight	368.01 g/mol
Synonyms	3-Bromo-1-benzothiophene-2-boronic acid N-methyliminodiacetic acid ester; 3-Bromobenzo[b]thiophene-2-boronic acid MIDA ester; 2-(3-Bromobenzo[b]thiophen-2-yl)-5,5-dimethyl-1,3,2-dioxaborinane MIDA analog; B-(3-Bromobenzo[b]thiophen-2-yl)-N-methyliminodiacetic acid boronate; 1104636-80-7; 3-Bromo-benzo[b]thiophene-2-boronic acid MIDA ester
EINECS	Contact for details

Quality Control

Every batch of 3-Bromobenzothiophene-2-Boronic Acid Mida Ester is produced and tested under strict quality management protocols to ensure consistency and purity for research and development applications. Our products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.