Description

Methyl 5-Chloro-2-Hydroxy-4-(Trifluoromethyl)Benzoate is a high-value trifluoromethylated aromatic ester building block, essential for advanced organic synthesis. Its unique structure, combining a phenolic hydroxyl group, a chloro substituent, and a trifluoromethyl group, makes it a critical intermediate for developing novel active compounds. This product is primarily targeted at research and development laboratories and production facilities in the pharmaceutical and agrochemical sectors seeking to incorporate fluorinated motifs into their molecules.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, anti-inflammatory agents, and anti-infectives where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Serves as a vital building block for developing next-generation herbicides, fungicides, and insecticides, leveraging the fluorine atoms to improve pesticidal activity, rainfastness, and environmental profile.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials where fluorinated aromatic units can modify solubility, thermal stability, and optical properties.
• Chemical Biology & Probe Development: Employed as a scaffold for creating molecular probes and enzyme inhibitors, utilizing the chloro and hydroxyl groups for further functionalization via coupling reactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and scale-up campaigns for client-specific molecules.

Basic Information

Product Name	Methyl 5-Chloro-2-Hydroxy-4-(Trifluoromethyl)Benzoate
CAS No.	1103837-39-3
Molecular Formula	C9H6ClF3O3
Molecular Weight	254.59 g/mol
Synonyms	5-Chloro-2-hydroxy-4-(trifluoromethyl)benzoic acid methyl ester; Methyl 5-chloro-2-hydroxy-4-trifluoromethylbenzoate; Benzoic acid, 5-chloro-2-hydroxy-4-(trifluoromethyl)-, methyl ester; 2-Hydroxy-5-chloro-4-trifluoromethylbenzoic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of Methyl 5-Chloro-2-Hydroxy-4-(Trifluoromethyl)Benzoate is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant techniques is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.