Description

3-(Trifluoromethylsulfonyl)Acetophenone is a high-value, specialty organic compound featuring a trifluoromethylsulfonyl (triflyl) group attached to an acetophenone core. This unique structure makes it a critical advanced pharmaceutical intermediate and a versatile building block in modern synthetic chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those requiring the introduction of the electron-withdrawing triflyl group to modulate bioactivity and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides where the trifluoromethylsulfonyl moiety enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Material Science Research: Employed in the development of advanced polymers and organic electronic materials due to its ability to influence electronic properties and solubility.
• Chemical Research & Development: A versatile reagent for introducing the triflyl group into aromatic systems, enabling structure-activity relationship (SAR) studies and the creation of novel chemical entities.

Basic Information

Product Name	3-(Trifluoromethylsulfonyl)Acetophenone
CAS No.	1100768-01-1
Molecular Formula	C9H7F3O3S
Molecular Weight	252.21 g/mol
Synonyms	1-[3-(Trifluoromethylsulfonyl)phenyl]ethanone; 3'-(Trifluoromethylsulfonyl)acetophenone; 3-(Triflyl)acetophenone; 1-Acetyl-3-(trifluoromethylsulfonyl)benzene; α-Methyl-3-(trifluoromethylsulfonyl)benzyl ketone; Ethanone, 1-[3-[(trifluoromethyl)sulfonyl]phenyl]-; 3-(Trifluoromethanesulfonyl)acetophenone
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethylsulfonyl)Acetophenone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the original container tightly sealed and consider storage under an inert atmosphere for long-term preservation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.