Description

2-Bromo-1-Methyl-3-(Trifluoromethyl)Benzene is a versatile halogenated aromatic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic combination of bromine and trifluoromethyl substituents, which enables precise functionalization and the introduction of lipophilicity and metabolic stability into target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing the trifluoromethyl group, which is a privileged motif in drug discovery.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the benzene core provides a stable scaffold for bioactive molecules.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and advanced organic materials with tailored properties.
• Ligand and Catalyst Development: Employed in the preparation of sophisticated ligands for transition metal catalysis and organocatalysts.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags used in biochemical and diagnostic research applications.
• Cross-Coupling Reactions: Acts as a reliable electrophilic partner in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.

Basic Information

Product Name	2-Bromo-1-Methyl-3-(Trifluoromethyl)Benzene
CAS No.	1099597-98-4
Molecular Formula	C9H6BrF3
Molecular Weight	251.05 g/mol
Synonyms	2-Bromo-α,α,α-trifluoro-m-xylene; 1-Bromo-2-methyl-3-(trifluoromethyl)benzene; 3-(Trifluoromethyl)-2-bromotoluene; 2-Methyl-6-(trifluoromethyl)bromobenzene; m-Xylene, 2-bromo-α,α,α-trifluoro-; Benzene, 2-bromo-1-methyl-3-(trifluoromethyl)-
EINECS	Contact for details

Quality Control

Our 2-Bromo-1-Methyl-3-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.