Description

4-(Chlorosulfonyl)-1H-Pyrrole-2-Carboxylic Acid is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters as a key precursor for constructing complex molecular architectures, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. Pharmaceutical researchers, agrochemical developers, and specialty chemical manufacturers need this intermediate for its reactive chlorosulfonyl and carboxylic acid groups, which enable precise derivatization and scaffold diversification.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting pyrrole-based scaffolds.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging its reactive sites for creating bioactive molecules.
• Material Science Research: Serves as a monomer or precursor for developing functional polymers, dyes, and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes (ABPs) and affinity tags due to its electrophilic chlorosulfonyl group, which can react with nucleophilic amino acids.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.
• Academic & Industrial R&D: Fundamental research reagent in heterocyclic chemistry for exploring new reaction pathways and creating compound libraries.

Basic Information

Product Name	4-(Chlorosulfonyl)-1H-Pyrrole-2-Carboxylic Acid
CAS No.	1096910-97-2
Molecular Formula	C5H4ClNO4S
Molecular Weight	209.61 g/mol
Synonyms	1H-Pyrrole-2-carboxylic acid, 4-(chlorosulfonyl)-; 4-Chlorosulfonyl-1H-pyrrole-2-carboxylic acid; Pyrrole-2-carboxylic acid, 4-(chlorosulfonyl)-; 4-(Chlorosulfonyl)pyrrole-2-carboxylic acid; 2-Carboxy-4-(chlorosulfonyl)pyrrole; 4-Chlorosulfonylpyrrole-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-(Chlorosulfonyl)-1H-Pyrrole-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed batch-specific data are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 2.0 %
Residue on Ignition	≤ 0.5 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.