Description

4-(Trifluoromethyl)Pyridine-2-Boronic Acid Pinacol Ester is a high-value organoboron building block, specifically a pyridine-substituted boronic ester. This compound is critical for enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing complex molecules containing a trifluoromethylpyridine moiety.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates containing the 4-(trifluoromethyl)pyridine scaffold.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Employed in the development of organic electronic materials, such as ligands for metal-organic frameworks (MOFs) or components for organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: Serves as a versatile coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to introduce the 2-substituted-4-(trifluoromethyl)pyridine unit into more complex structures.
• Chemical Biology & Medicinal Chemistry: Utilized in the design and synthesis of molecular probes, enzyme inhibitors, and other bioactive compounds for target identification and validation studies.

Basic Information

Product Name	4-(Trifluoromethyl)Pyridine-2-Boronic Acid Pinacol Ester
CAS No.	1096689-46-1
Molecular Formula	C13H15BF3NO2
Molecular Weight	285.07 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 4-(Trifluoromethyl)pyridine-2-boronic acid pinacol ester; 2-Pyridineboronic acid, 4-(trifluoromethyl)-, 1,1-dimethylethyl ester; 4-Trifluoromethyl-2-pyridineboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyridine-2-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to guarantee compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light) and should be handled under an inert atmosphere when appropriate for prolonged use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.