Description

3-(2,5-Difluoro-Phenyl)-4,5-Dihydro-Isoxazole-5-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique isoxazoline-carboxylic acid scaffold. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel active pharmaceutical ingredients (APIs) with targeted therapeutic effects. It is primarily needed by R&D scientists and process chemists in the pharmaceutical, agrochemical, and fine chemical industries for developing new drug candidates and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of new drug molecules, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Serves as a precursor in the creation of novel herbicides and pesticides, leveraging the biological activity of the difluorophenyl and isoxazoline motifs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical entities.
• Fine Chemical Production: Employed in the custom synthesis of complex, high-value specialty chemicals for various industrial applications.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs for scale-up and GMP manufacturing of client-specific compounds.
• Academic Research: Utilized in university and institutional labs for synthetic methodology development and bioorganic chemistry studies.

Basic Information

Product Name	3-(2,5-Difluoro-Phenyl)-4,5-Dihydro-Isoxazole-5-Carboxylic Acid
CAS No.	1096348-81-0
Molecular Formula	C10H7F2NO3
Molecular Weight	227.16 g/mol
Synonyms	5-Isoxazolecarboxylic acid, 4,5-dihydro-3-(2,5-difluorophenyl)-; 3-(2,5-Difluorophenyl)-4,5-dihydroisoxazole-5-carboxylic acid; 2,5-Difluoro-β-(5-carboxy-4,5-dihydroisoxazol-3-yl)benzene; 1096348-81-0; 5-Carboxy-3-(2,5-difluorophenyl)-4,5-dihydroisoxazole; 3-(2,5-Difluorophenyl)-δ²-isoxazoline-5-carboxylic acid
EINECS	Contact for details

Quality Control

Our 3-(2,5-Difluorophenyl)-4,5-dihydroisoxazole-5-carboxylic acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.