Description

1-Bromo-2-Fluoro-4,5-Dimethoxybenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and methoxy substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, material science, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in the synthesis of fluorinated drug candidates where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the halogenated aromatic core for biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials, where the dimethoxy and halogen groups help fine-tune molecular polarity and mesomorphic properties.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig aminations, where the bromine acts as a superior leaving group compared to chlorine.
• Chemical Research & Development: Employed as a standard or custom building block in academic and industrial R&D labs for exploring new synthetic methodologies and creating compound libraries.
• Fluorine Chemistry Studies: Utilized in studies investigating the ortho-effect and electronic influences of adjacent fluorine and methoxy groups on aromatic substitution reactions.

Basic Information

Item	Details
Product Name	1-Bromo-2-Fluoro-4,5-Dimethoxybenzene
CAS No.	1095544-81-2
Molecular Formula	C8H8BrFO2
Molecular Weight	235.05 g/mol
Synonyms	2-Bromo-1-Fluoro-4,5-Dimethoxybenzene; 4-Bromo-5-Fluoro-1,2-Dimethoxybenzene; Benzene, 1-bromo-2-fluoro-4,5-dimethoxy-; 1,2-Dimethoxy-4-bromo-5-fluorobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Fluoro-4,5-Dimethoxybenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all test results are provided with every shipment and are available upon request. We support custom synthesis and can tailor specifications to meet specific project requirements, including cGMP standards for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.