Description

1-Bromo-4-Ethoxy-2-Fluoro-5-Methoxybenzene is a high-purity, multi-functional halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in its precisely positioned bromo, fluoro, and alkoxy substituents, which enable selective cross-coupling reactions and serve as key intermediates for complex molecular architectures. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates where the fluorine atom enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the halogen and alkoxy groups for targeted biological activity.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands used in transition metal catalysis, such as palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig).
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers where specific substitution patterns are required to tune electronic and physical properties.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-Bromo-4-Ethoxy-2-Fluoro-5-Methoxybenzene
CAS No.	1095544-33-4
Molecular Formula	C9H10BrFO2
Molecular Weight	249.08 g/mol
Synonyms	4-Bromo-1-ethoxy-2-fluoro-5-methoxybenzene; 2-Fluoro-4-bromo-1-ethoxy-5-methoxybenzene; Benzene, 1-bromo-4-ethoxy-2-fluoro-5-methoxy-; 1-Bromo-4-ethoxy-2-fluoro-5-methoxybenzene; 4-Bromo-2-fluoro-1,5-dimethoxybenzene (related isomer); 2-Fluoro-4-bromo-5-methoxyphenetole
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-Ethoxy-2-Fluoro-5-Methoxybenzene is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support cGMP compliance for pharmaceutical applications and can provide materials that meet the stringent requirements for advanced research and process scale-up.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is light-sensitive (store away from light) and should be handled under an inert atmosphere for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.