Description

1-(2,4-Difluorophenyl)-3,3,3-Trifluoropropan-1-One is a high-value fluorinated aromatic ketone building block, prized for its unique molecular architecture that combines difluorophenyl and trifluoromethyl groups. This compound is critical for introducing lipophilicity, metabolic stability, and electronic effects into advanced molecular frameworks. It is primarily sought by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients, including kinase inhibitors and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the fluorine atoms enhance bioavailability and environmental persistence.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, leveraging its aromatic and fluorinated properties.
• Chemical Research (R&D): Employed in academic and industrial laboratories for method development and exploring novel fluorination chemistry.
• Ligand and Catalyst Development: Utilized in the design of novel ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	1-(2,4-Difluorophenyl)-3,3,3-Trifluoropropan-1-One
CAS No.	1094374-10-3
Molecular Formula	C9H5F5O
Molecular Weight	224.13 g/mol
Synonyms	2,4-Difluoro-3',3',3'-trifluoropropiophenone; 3,3,3-Trifluoro-1-(2,4-difluorophenyl)-1-propanone; 1-Propanone, 3,3,3-trifluoro-1-(2,4-difluorophenyl)-; 2',4'-Difluoro-3,3,3-trifluoropropiophenone; (2,4-Difluorophenyl)(3,3,3-trifluoropropyl)methanone
EINECS	Contact for details

Quality Control

Our production of 1-(2,4-Difluorophenyl)-3,3,3-Trifluoropropan-1-One adheres to stringent in-process controls and final batch analysis to ensure consistent high purity and reliable performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality management system is designed to support cGMP and ISO standards for traceability and reproducibility, making this material suitable for demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.