Description

1-(4-Chlorophenyl)-2-(3-Fluorophenyl)Ethanone is a high-purity fluorinated and chlorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique bifunctional structure, featuring both electron-withdrawing chloro and fluoro substituents on distinct aromatic rings, makes it a versatile precursor for constructing complex molecular architectures. This compound is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and anti-inflammatory targets.
• Agrochemical Synthesis: Serves as a core building block for creating advanced herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Ligand and Catalyst Development: Used in the preparation of specialized ligands for transition metal catalysis and organocatalysts due to its tunable electronic properties.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and polymers where fluorinated and chlorinated aromatic units are required.
• Custom Chemical Synthesis: A valuable starting material for contract research organizations (CROs) and custom synthesis providers working on client-specific molecular targets.
• Academic Research: Utilized in university laboratories for methodological studies in cross-coupling reactions, carbonyl chemistry, and heterocycle formation.

Basic Information

Product Name	1-(4-Chlorophenyl)-2-(3-Fluorophenyl)Ethanone
CAS No.	1094313-25-3
Molecular Formula	C14H10ClFO
Molecular Weight	248.68 g/mol
Synonyms	3'-Fluoro-4'-chlorochalcone; 1-(4-Chlorophenyl)-2-(3-fluorophenyl)ethan-1-one; 2-(3-Fluorophenyl)-1-(4-chlorophenyl)ethanone; (3-Fluorophenyl)(4-chlorophenyl)methanone (tautomeric form); 4-Chloro-3'-fluorochalcone; 4'-Chloro-3-fluorochalcone; 3-Fluoro-4-chlorochalcone; 4-Chlorophenyl 3-fluorophenyl ketone
EINECS	Contact for details

Quality Control

Every batch of 1-(4-Chlorophenyl)-2-(3-Fluorophenyl)Ethanone is manufactured under a strict quality management system and undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with specifications for residual solvents and related substances. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting results from techniques including HPLC, GC, NMR, and IR spectroscopy.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive (store away from light) and should be kept under an inert atmosphere for long-term storage to prevent potential degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.