Description

1-(2,5-Difluorophenyl)-2-Methylpropan-1-One is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its value lies in its unique difluorophenyl moiety, which is strategically incorporated into target molecules to modulate their physicochemical and metabolic properties. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, serving as a key intermediate for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalizing agent in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Chemical Biology & Probe Development: Employed as a building block for creating fluorescent probes, enzyme inhibitors, and other tools for biochemical and diagnostic research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in bespoke synthesis projects and scale-up campaigns.

Basic Information

Product Name	1-(2,5-Difluorophenyl)-2-Methylpropan-1-One
CAS No.	1094292-49-5
Molecular Formula	C10H10F2O
Molecular Weight	184.18 g/mol
Synonyms	2,5-Difluorophenyl isopropyl ketone; 2-Methyl-1-(2,5-difluorophenyl)propan-1-one; α,α-Dimethyl-2,5-difluoroacetophenone; Isopropyl 2,5-difluorophenyl ketone; 1-(2,5-Difluorophenyl)-2-methyl-1-propanone; 2,5-Difluoro-α,α-dimethylacetophenone; 2,5-Difluorophenyl 1-methylethyl ketone
EINECS	Contact for details

Quality Control

Our 1-(2,5-Difluorophenyl)-2-Methylpropan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high standards, including cGMP development and non-GMP research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents, strong bases, and sources of ignition. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.