Description

4,4-Difluoroazepane is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the strategic introduction of fluorine atoms and a seven-membered azepane ring, which are critical for modulating the physicochemical and biological properties of target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the design and development of new-generation pesticides and herbicides, where the difluoroazepane moiety can enhance bioavailability and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in asymmetric catalysis and transition metal complexes.
• Material Science: Employed in the synthesis of advanced polymers and functional materials that require fluorinated nitrogen-containing heterocycles.
• Chemical Biology Probe Synthesis: Utilized to create molecular probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Product Name	4,4-Difluoroazepane
CAS No.	1094073-72-9
Molecular Formula	C6H11F2N
Molecular Weight	135.16 g/mol
Synonyms	4,4-Difluoroazepane; 4,4-Difluorohexahydro-1H-azepine; Hexahydro-4,4-difluoro-1H-azepine; 1H-Azepine, hexahydro-4,4-difluoro-; Azepane, 4,4-difluoro-; 4,4-Difluoro-perhydroazepine
EINECS	Contact for details

Quality Control

Our 4,4-Difluoroazepane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its chemical nature as a fluoride/strong alkali, it should be kept separate from incompatible materials such as strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.