Description

Boronic Acid, B-[2,6-Difluoro-4-(4-Morpholinyl)Phenyl]- is a high-purity, functionalized arylboronic acid derivative of significant importance in modern synthetic chemistry. Its core value lies in its role as a versatile building block for the Suzuki-Miyaura cross-coupling reaction, a cornerstone methodology for forming carbon-carbon bonds. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require precise molecular construction for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the morpholine and difluoro substituents for bioactivity.
• Material Science: Serves as a key monomer or cross-linking agent in the development of organic electronic materials, such as polymers for OLEDs and OFETs.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, enzyme inhibitors, and bioconjugation reagents due to its specific reactivity.
• Ligand Synthesis for Catalysis: Used to create sophisticated bidentate or tridentate ligands for transition metal catalysts used in asymmetric synthesis.
• Library Synthesis for Drug Discovery: A valuable building block in parallel and combinatorial chemistry for generating diverse compound libraries for high-throughput screening.

Basic Information

Product Name	Boronic Acid, B-[2,6-Difluoro-4-(4-Morpholinyl)Phenyl]-
CAS No.	1093878-46-6
Molecular Formula	C10H12BF2NO3
Molecular Weight	251.02 g/mol
Synonyms	2,6-Difluoro-4-morpholinophenylboronic Acid; (2,6-Difluoro-4-morpholin-4-ylphenyl)boronic Acid; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3,5-difluoromorpholinobenzene (Pinacol Ester Precursor); B-(2,6-Difluoro-4-morpholinophenyl)boronic Acid; 2,6-Difluoro-4-morpholinobenzeneboronic Acid; 1093878-46-6; 4-Morpholino-2,6-difluorophenylboronic Acid
EINECS	Contact for details

Quality Control

Every batch of Boronic Acid, B-[2,6-Difluoro-4-(4-Morpholinyl)Phenyl]- is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for sensitive applications like pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters including assay (HPLC), identity (NMR, IR), and impurity profiles. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (HPLC)	≥98.0% (Total area %)
Water Content (KF)	≤0.5%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.