Description

1H-Pyrazolo[3,4-B]Pyridine-5-Boronic Acid Pinacol Ester is a high-value boronic ester derivative, a crucial building block in modern synthetic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone method for constructing complex carbon-carbon bonds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to synthesize novel active ingredients and functional molecules. Its pinacol ester group enhances stability, making it a preferred reagent for demanding synthetic sequences.

Application

• Pharmaceutical Intermediate: A key synthon for constructing pyrazolopyridine-based drug candidates in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides with pyrazolopyridine scaffolds.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological pathways and target engagement.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.
• Process Chemistry: Employed in the scale-up and optimization of synthetic routes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	1H-Pyrazolo[3,4-B]Pyridine-5-Boronic Acid Pinacol Ester
CAS No.	1093819-50-1
Molecular Formula	C14H18BN3O2
Molecular Weight	271.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine; 1H-Pyrazolo[3,4-b]pyridine-5-boronic acid pinacol ester; Pyrazolo[3,4-b]pyridin-5-ylboronic acid pinacol ester; 5-Borono-1H-pyrazolo[3,4-b]pyridine pinacol ester; 1093819-50-1; 1H-Pyrazolo[3,4-B]Pyridine-5-Boronic Acid Pinacol Ester; 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazolo[3,4-b]pyridine
EINECS	Contact for details

Quality Control

Our 1H-Pyrazolo[3,4-B]Pyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical cross-coupling applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available for every shipment. We adhere to cGMP principles for pharmaceutical-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.