Description

tert-Butyl 4-acetamidopiperidin-1-carboxylate is a high-purity, protected piperidine derivative serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile and reactive scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This intermediate is essential for medicinal chemists and process development scientists working on new active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Protease Inhibitor Synthesis: Used in the development of protease inhibitors, a major class of antiviral and anticancer agents.
• Kinase Inhibitor Development: Serves as a core structural component in the creation of selective kinase inhibitors for oncology and inflammatory diseases.
• Peptidomimetic Chemistry: Employed to introduce the 4-acetamidopiperidine moiety into peptidomimetic structures to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the construction of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis projects and scale-up processes under cGMP or research-grade conditions.

Basic Information

Item	Details
Product Name	tert-Butyl 4-Acetamidopiperidin-1-Carboxylate
CAS No.	1093759-67-1
Molecular Formula	C12H22N2O3
Molecular Weight	242.32 g/mol
Synonyms	1-Boc-4-acetamidopiperidine; 4-Acetamido-1-piperidinecarboxylic Acid 1,1-Dimethylethyl Ester; 1-(tert-Butoxycarbonyl)-4-acetamidopiperidine; N-(1-Boc-piperidin-4-yl)acetamide; tert-Butyl N-(4-acetamidopiperidin-1-yl)carboxylate; 4-Acetamidopiperidine-1-carboxylic Acid tert-Butyl Ester; Boc-4-Acetamidopiperidine
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-acetamidopiperidin-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.