Description

3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Propanamide is a high-value, organoboron-protected pyrazole derivative, serving as a critical synthetic intermediate in modern pharmaceutical and agrochemical research. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for medicinal chemists and process development scientists engaged in the discovery and optimization of novel active ingredients. The CAS number for this compound is 1093307-34-6.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and oncology drug discovery programs.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides requiring complex heterocyclic scaffolds.
• Material Science: Potential precursor for creating functional organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology: Employed in the synthesis of molecular probes and bioconjugates for studying biological pathways and protein interactions.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura couplings to introduce the pyrazole-propanamide moiety into target molecules.
• Library Synthesis: Valuable scaffold for generating diverse compound libraries in high-throughput screening for drug discovery.

Basic Information

Product Name	3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Propanamide
CAS No.	1093307-34-6
Molecular Formula	C₁₄H₂₄BN₃O₃
Molecular Weight	293.17 g/mol
Synonyms	3-[4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]propanamide; 1H-Pyrazole-1-propanamide, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Propanamide, 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]-; 1093307-34-6; 3-(4-(Pinacolatoboryl)-1H-pyrazol-1-yl)propanamide; 4-(Pinacolatoboryl)-1H-pyrazole-1-propanamide
EINECS	Contact for details

Quality Control

Every batch of our 3-(4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl)Propanamide is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.