Description

1-(2,6-Difluorophenyl)-2,2,2-Trifluoroethan-1-One is a high-purity fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. This compound is valued for its unique trifluoroacetyl group and difluorinated aromatic ring, which are critical for modulating the electronic properties, metabolic stability, and lipophilicity of target molecules. It serves as a key synthetic intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of fluorinated drug candidates targeting central nervous system (CNS) disorders, anti-infectives, and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials that benefit from fluorinated aromatic units.
• Chemical Biology & Proteomics: Employed as a reactive handle or linker in the design of chemical probes, affinity tags, and enzyme inhibitors for biochemical research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in custom synthesis projects and process development for client molecules.

Basic Information

Product Name	1-(2,6-Difluorophenyl)-2,2,2-Trifluoroethan-1-One
CAS No.	1092712-26-9
Molecular Formula	C8H3F5O
Molecular Weight	210.10 g/mol
Synonyms	2,6-Difluoro-α,α,α-trifluoroacetophenone; 2',6'-Difluoro-2,2,2-trifluoroacetophenone; 1-(2,6-Difluorophenyl)-2,2,2-trifluoroethanone; 2,6-Difluorophenyl trifluoromethyl ketone; α,α,α-Trifluoro-2,6-difluoroacetophenone; (2,6-Difluorophenyl)(trifluoromethyl)methanone; TFAP-2,6-dF
EINECS	Contact for details

Quality Control

Our 1-(2,6-Difluorophenyl)-2,2,2-Trifluoroethan-1-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.