Description

2-(4-Chloro-5-Fluoro-2-Methoxy-Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality intermediates for drug discovery and development.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used to construct complex heterocyclic structures found in modern herbicides, fungicides, and insecticides, contributing to crop protection solutions.
• Material Science Research: Serves as a monomer or functionalization agent in the development of organic electronic materials, such as polymers for OLEDs and organic photovoltaics.
• Chemical Biology & Probe Development: Employed in the synthesis of bioconjugates and molecular probes for diagnostic and biochemical research applications.
• Process Chemistry & Scale-up: Provides a stable, handleable boronate source for optimizing and scaling up synthetic routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	2-(4-Chloro-5-Fluoro-2-Methoxy-Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	1092581-00-4
Molecular Formula	C₁₃H₁₈BClFO₃
Molecular Weight	287.54 g/mol
Synonyms	4-Chloro-5-fluoro-2-methoxyphenylboronic acid pinacol ester; (4-Chloro-5-fluoro-2-methoxyphenyl)boronic acid pinacol ester; 2-Methoxy-4-chloro-5-fluorophenylboronic acid pinacol ester; Pinacol (4-chloro-5-fluoro-2-methoxyphenyl)boronate; 4-Chloro-5-fluoro-2-methoxybenzeneboronic acid pinacol ester; 1092581-00-4; B-(4-Chloro-5-fluoro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Every batch of our 2-(4-Chloro-5-Fluoro-2-Methoxy-Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.