Description

tert-Butyl 4-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Methyl}Piperidine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected piperidine scaffold and a pinacol boronate ester functional group. This compound is a critical building block in modern medicinal chemistry, enabling efficient cross-coupling reactions for the synthesis of novel drug candidates. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of small molecule therapeutics, particularly in oncology and central nervous system (CNS) disorders.

Application

• Suzuki-Miyaura Cross-Coupling Reagent: Acts as a key boron-containing coupling partner for constructing complex biaryl and heterobiaryl structures in drug discovery.
• Pharmaceutical Intermediate: Serves as a versatile precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Used in library synthesis for structure-activity relationship (SAR) studies and lead optimization programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Employed in the synthesis of linker components or warhead ligands for novel bifunctional degrader molecules.
• Chemical Biology Probe Synthesis: Facilitates the creation of tagged molecules for studying biological targets and mechanisms of action.
• Agrochemical Research: Potential intermediate in the development of new active ingredients for crop protection.

Basic Information

Product Name	tert-Butyl 4-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Methyl}Piperidine-1-Carboxylate
CAS No.	1092563-72-8
Molecular Formula	C19H34BN3O4
Molecular Weight	379.30 g/mol
Synonyms	1-Boc-4-[(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl]piperidine; tert-Butyl 4-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate; 1,1-Dimethylethyl 4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl]-1-piperidinecarboxylate; 4-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylic acid tert-butyl ester; BOC-Piperidine-Pyrazole-Boronic Acid Pinacol Ester; 1092563-72-8
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-{[4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-1H-Pyrazol-1-Yl]Methyl}Piperidine-1-Carboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request, supporting compliance with internal quality standards for pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.