Description

3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrazol-1-Ylmethyl]-Piperidine-1-Carboxylic Acid tert-Butyl Ester is a high-value, multi-functional chemical building block that integrates a protected piperidine scaffold with a pyrazole-boronic ester moiety. This compound is critical for enabling advanced synthetic routes in medicinal chemistry, particularly in the construction of complex, nitrogen-containing heterocycles. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for applications in drug discovery, process development, and the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Suzuki-Miyaura Cross-Coupling Reactions: The pinacol boronate ester group serves as a key coupling partner for the synthesis of biaryl and heteroaryl structures, a cornerstone reaction in modern drug development.
• Pharmaceutical Intermediate Synthesis: Used as a versatile precursor in the multi-step synthesis of potential therapeutic agents targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Library Synthesis for High-Throughput Screening: Enables the rapid generation of diverse compound libraries by medicinal chemists exploring new chemical space for hit identification and lead optimization.
• Peptidomimetic and Bioisostere Development: The piperidine-carboxylate framework is valuable for creating conformationally restricted analogs and bioisosteres of peptide motifs.
• Ligand and Catalyst Development: Can be utilized in the design and synthesis of novel ligands for asymmetric catalysis or metal-organic frameworks (MOFs).
• Agrochemical Research: Applied in the discovery and synthesis of new crop protection agents and pesticides with novel modes of action.

Basic Information

Item	Details
Product Name	3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrazol-1-Ylmethyl]-Piperidine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	1092563-71-7
Molecular Formula	C20H34BN3O4
Molecular Weight	391.32 g/mol
Synonyms	1-Boc-3-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine; tert-Butyl 3-((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylate; 1,1-Dimethylethyl 3-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl]-1-piperidinecarboxylate; 3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine-1-carboxylic acid tert-butyl ester; Boc-3-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)piperidine
EINECS	Contact for details

Quality Control

Our production of 3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrazol-1-Ylmethyl]-Piperidine-1-Carboxylic Acid tert-Butyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up processes. All products undergo rigorous analytical testing, including HPLC, NMR (1H and 13C), and mass spectrometry, to confirm identity and purity. Comprehensive Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with every shipment. We operate under a quality management system and can supply material compliant with cGMP standards for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C in a freezer. This compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to decomposition. Allow the sealed container to equilibrate to room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥ 97.0% (Area Percent)
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.