Description

1-(1-Boc-4-Piperidyl)-3-Methylpyrazole-4-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate belonging to the class of protected piperidine boronic esters. This compound is a critical building block in modern medicinal chemistry, valued for its role in facilitating efficient Suzuki-Miyaura cross-coupling reactions. It is primarily utilized by research and development teams in the pharmaceutical and biotechnology sectors for the synthesis of novel drug candidates, particularly in the development of targeted small molecule therapies. Its stable pinacol ester form offers enhanced handling characteristics for complex multi-step synthetic routes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for constructing biaryl and heterobiaryl structures central to many drug molecules.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening and library synthesis for lead optimization and structure-activity relationship (SAR) studies.
• Protease Inhibitor Development: Found in synthetic pathways for compounds targeting proteases, given the piperidine scaffold's prevalence.
• Kinase Inhibitor Research: Employed in the construction of heterocyclic cores common in kinase inhibitor candidates for oncology and inflammatory diseases.
• Chemical Biology Probes: Utilized to create tagged or modified molecules for studying biological pathways and target engagement.

Basic Information

Product Name	1-(1-Boc-4-Piperidyl)-3-Methylpyrazole-4-Boronic Acid Pinacol Ester
CAS No.	1092563-68-2
Molecular Formula	C20H34BN3O4
Molecular Weight	391.32 g/mol
Synonyms	1-(1-Boc-4-Piperidyl)-3-methyl-1H-pyrazole-4-boronic acid pinacol ester; 1-(1-tert-Butoxycarbonyl-4-piperidinyl)-3-methyl-1H-pyrazole-4-boronic acid pinacol ester; 3-Methyl-1-[1-(tert-butoxycarbonyl)-4-piperidinyl]-1H-pyrazole-4-boronic acid pinacol ester; 1-(1-Boc-piperidin-4-yl)-3-methyl-1H-pyrazole-4-boronic acid pinacol ester; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(1-Boc-4-piperidyl)-3-methylpyrazole; BOC-Piperidine-Pyrazole-Boronic Ester; tert-Butyl 4-[3-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our 1-(1-Boc-4-Piperidyl)-3-Methylpyrazole-4-Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, meeting the exacting standards required for pharmaceutical R&D. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry guidelines to support our clients' regulatory and quality system requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.