Description

(2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)(Morpholino)Methanone is a high-value, multifunctional organic building block that integrates a boronic ester pinacol group with a morpholine amide moiety. This compound matters for its critical role as a key intermediate in modern synthetic chemistry, particularly in cross-coupling reactions like the Suzuki-Miyaura reaction, enabling the efficient construction of complex molecular architectures. It is primarily needed by research and development teams in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in medicinal chemistry programs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its boronic ester functionality for structural diversification.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics, due to its conjugated system.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester group makes it an ideal partner for palladium-catalyzed coupling with aryl/vinyl halides, a cornerstone reaction in complex molecule assembly.
• Ligand and Catalyst Development: The morpholine carbonyl group can act as a coordinating site or be further modified to create novel ligands for catalysis.
• Chemical Biology Probes: Utilized in the synthesis of labeled compounds and molecular probes for studying biological pathways and target engagement.

Basic Information

Item	Details
Product Name	(2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)(Morpholino)Methanone
CAS No.	1092563-48-8
Molecular Formula	C17H23BClNO4
Molecular Weight	351.63 g/mol
Synonyms	4-(2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)morpholine; 2-Chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid morpholide; (2-Chloro-4-(pinacolatoboron)phenyl)(morpholino)methanone; Morpholino(2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone; 2-Chloro-4-(pinacolboron)benzoyl morpholine; 1092563-48-8; Boronic acid, B-[2-chloro-4-(morpholinocarbonyl)phenyl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our (2-Chloro-4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl)(Morpholino)Methanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term preservation and to minimize degradation. Recommended storage temperature: 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.