Description

4-[4-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-Yl)Benzyl]Thiomorpholine 1,1-Dioxide is a high-value, multi-functional organic building block featuring a protected boronic ester group and a sulfonated thiomorpholine moiety. This compound is critical for enabling complex molecular synthesis through key cross-coupling reactions, offering researchers and process chemists a versatile tool for constructing advanced chemical architectures. It is primarily sought after by the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex boron-containing scaffolds.
• Material Science: Serves as a monomer or functionalizing agent in the synthesis of organic electronic materials, such as OLEDs and conductive polymers.
• Chemical Biology & Proteomics: Employed as a building block for creating activity-based probes and bioconjugation reagents targeting sulfonamide-interacting proteins.
• Ligand Development: Utilized in the synthesis of novel ligands for catalysis, leveraging the sulfone and amine functionalities for metal coordination.
• Library Synthesis for Drug Discovery: An essential component in parallel and combinatorial chemistry to generate diverse compound libraries for high-throughput screening.

Basic Information

Product Name	4-[4-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-Yl)Benzyl]Thiomorpholine 1,1-Dioxide
CAS No.	1092563-25-1
Molecular Formula	C17H26BNO4S
Molecular Weight	351.27 g/mol
Synonyms	4-[(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methyl]thiomorpholine 1,1-dioxide; 2-[4-[(1,1-Dioxidothiomorpholin-4-yl)methyl]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)thiomorpholine 1,1-dioxide; Thiomorpholine, 4-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methyl]-, 1,1-dioxide; Pinacol [4-[(1,1-Dioxidothiomorpholin-4-yl)methyl]phenyl]boronate; 4-(4-Pinacolatoborylbenzyl)thiomorpholine 1,1-dioxide
EINECS	Contact for details

Quality Control

Every batch of 4-[4-(4,4,5,5-Tetramethyl[1,3,2]Dioxaborolan-2-Yl)Benzyl]Thiomorpholine 1,1-Dioxide is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and mass spectrometry, is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent oxidation and hydrolysis of the boronic ester. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.