Description

4-{[2-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Carbonyl}Morpholine is a high-value, synthetically versatile boronic ester derivative that serves as a critical building block in modern organic synthesis. Its core value lies in enabling the precise construction of complex molecules through reliable cross-coupling reactions, particularly the Suzuki-Miyaura reaction. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who are developing new active ingredients, as well as for advanced material scientists working on organic electronic components.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for compounds containing biaryl or heterobiaryl motifs.
• Agrochemical Research: Used in the discovery and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science: Serves as a monomer or building block for creating advanced polymers, liquid crystals, and organic light-emitting diode (OLED) materials.
• Chemical Biology & Probe Development: Employed in the synthesis of molecular probes and tags for studying biological processes and target engagement.
• Cross-Coupling Reactions: Primarily utilized in palladium-catalyzed Suzuki-Miyaura cross-coupling to form carbon-carbon bonds with high efficiency and selectivity.
• Library Synthesis for Drug Discovery: Enables the rapid generation of diverse compound libraries for high-throughput screening in medicinal chemistry programs.

Basic Information

Item	Details
Product Name	4-{[2-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Carbonyl}Morpholine
CAS No.	1092563-24-0
Molecular Formula	C17H23BFNO4
Molecular Weight	335.18 g/mol
Synonyms	2-Fluoro-4-(morpholine-4-carbonyl)phenylboronic acid pinacol ester; (2-Fluoro-4-(morpholine-4-carbonyl)phenyl)boronic acid pinacol ester; 4-[2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]morpholine; Morpholine, 4-[[2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]carbonyl]-; 1092563-24-0; 4-(2-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)morpholine
EINECS	Contact for details

Quality Control

Our production of 4-{[2-Fluoro-4-(Tetramethyl-1,3,2-Dioxaborolan-2-Yl)Phenyl]Carbonyl}Morpholine adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for your critical synthetic steps. Each lot undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. Our quality management system is designed to support cGMP and ISO standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is light-sensitive (store away from light). Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and potential degradation. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.