Description

8-[4-[4-(4-Chlorophenzyl)Piperazide-1-Sulfonyl)Phenyl]]-1-Propylxanthine is a high-purity, specialized xanthine derivative designed for advanced research and development. This compound is valued for its role as a potent and selective chemical probe in pharmacological studies, particularly in the investigation of adenosine receptor signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and fine chemical manufacturers engaged in developing novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and screening of new drug candidates targeting neurological and cardiovascular disorders.
• Biochemical Assay Development: Used as a selective antagonist in in vitro and in vivo assays to study adenosine A1 and A2A receptor functions.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental research into purinergic signaling and related physiological processes.
• Fine Chemical Synthesis: Acts as a critical building block for the custom synthesis of more complex xanthine-based molecules with tailored biological activity.
• Reference Standard Production: Supplied as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	8-[4-[4-(4-Chlorophenzyl)Piperazide-1-Sulfonyl)Phenyl]]-1-Propylxanthine
CAS No.	1092351-10-4
Molecular Formula	C23H27ClN6O3S
Molecular Weight	503.02 g/mol
Synonyms	1-Propyl-8-[4-[[4-[(4-chlorophenyl)methyl]-1-piperazinyl]sulfonyl]phenyl]xanthine; PSB-603; 8-(4-(4-(4-Chlorobenzyl)piperazine-1-sulfonyl)phenyl)-1-propyl-3,7-dihydropurine-2,6-dione; Adenosine A2B Receptor Antagonist PSB-603; PSB 603; A2B Adenosine Receptor Antagonist
EINECS	Contact for details

Quality Control

Our 8-[4-[4-(4-Chlorophenzyl)Piperazide-1-Sulfonyl)Phenyl]]-1-Propylxanthine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.