Description

1,3-Difluoro-5-(2,2,2-Trifluoroethyl)Benzene is a high-purity fluorinated aromatic building block of significant commercial interest. This compound is valued for its unique electronic properties and stability, making it a critical intermediate in advanced chemical synthesis. It is primarily sought after by researchers and manufacturers in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in fluorine-containing drug candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the trifluoroethyl and difluoro motifs enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated components for electronic display materials and organic light-emitting diodes (OLEDs).
• Polymer & Resin Modification: Incorporated as a monomer or modifier to impart specific properties like chemical resistance, thermal stability, and low surface energy to advanced polymers.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitution to create complex, fluorinated molecular architectures.
• Material Science Research: Employed in the development of novel fluorinated materials for coatings, membranes, and specialty chemicals.

Basic Information

Product Name	1,3-Difluoro-5-(2,2,2-Trifluoroethyl)Benzene
CAS No.	1092350-20-3
Molecular Formula	C8H5F5
Molecular Weight	220.12 g/mol
Synonyms	5-(2,2,2-Trifluoroethyl)-1,3-difluorobenzene; 1,3-Difluoro-5-(trifluoroethyl)benzene; 3,5-Difluorobenzyltrifluoride; (2,2,2-Trifluoroethyl)-3,5-difluorobenzene; 3,5-Difluoro(trifluoroethyl)benzene; m-Difluoro(trifluoroethyl)benzene; Benzene, 1,3-difluoro-5-(2,2,2-trifluoroethyl)-
EINECS	Contact for details

Quality Control

Our 1,3-Difluoro-5-(2,2,2-Trifluoroethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistent quality suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is between 2°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (GC)	Individual impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.