Description

2,4-Dichloro-1-(2,2,2-trifluoroethyl)-benzene is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its unique structure, featuring both chloro and trifluoroethyl substituents, makes it a valuable precursor for creating complex molecules with tailored electronic and steric properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those requiring fluorinated motifs to modulate bioavailability, metabolic stability, and binding affinity.
• Agrochemical Research: Serves as a core structure in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoroethyl group can enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Used in the research and production of advanced electronic materials, where its aromatic and fluorinated nature contributes to desired dielectric and luminescent properties.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic aromatic substitutions to introduce the 2,4-dichloro-1-(2,2,2-trifluoroethyl)phenyl moiety into more complex architectures.
• Ligand & Catalyst Development: Acts as a precursor for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	2,4-Dichloro-1-(2,2,2-trifluoroethyl)-benzene
CAS No.	1092350-09-8
Molecular Formula	C8H5Cl2F3
Molecular Weight	229.03 g/mol
Synonyms	1-(2,2,2-Trifluoroethyl)-2,4-dichlorobenzene; 2,4-Dichloro-α,α,α-trifluoroethylbenzene; Benzene, 2,4-dichloro-1-(2,2,2-trifluoroethyl)-; (2,4-Dichlorophenyl)(trifluoro)methane (common misnomer); 2,4-Dichloro-1-(trifluoroethyl)benzene
EINECS	Contact for details

Quality Control

Every batch of 2,4-Dichloro-1-(2,2,2-trifluoroethyl)-benzene is manufactured and analyzed under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthetic pathway. A detailed Certificate of Analysis (COA), including purity by GC/HPLC and identity confirmation (IR, NMR), is supplied with each shipment to guarantee traceability and batch-to-batch consistency for your R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.