Description

8-Chloro-6-Fluorochroman-4-One is a high-purity fluorinated chromanone derivative, serving as a critical advanced pharmaceutical intermediate. Its value lies in its unique halogenated structure, which is essential for modulating the biological activity and pharmacokinetic properties of target drug molecules. This compound is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, particularly within medicinal chemistry and process R&D.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) with potential central nervous system (CNS) or anti-inflammatory activity.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore and optimize new chemical entities for drug discovery programs.
• Process Chemistry Development: Serves as a starting material or intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Organic Synthesis Reagent: Employed in academic and industrial laboratories for constructing complex heterocyclic frameworks due to its reactive ketone and halogen functional groups.
• Reference Standard: Utilized as an analytical standard for quality control and method development in pharmaceutical analysis.

Basic Information

Product Name	8-Chloro-6-Fluorochroman-4-One
CAS No.	1092349-40-0
Molecular Formula	C9H6ClFO2
Molecular Weight	200.59 g/mol
Synonyms	8-Chloro-6-fluorochroman-4-one; 4H-1-Benzopyran-4-one, 8-chloro-6-fluoro-2,3-dihydro-; 8-Chloro-6-fluoro-2,3-dihydro-4H-chromen-4-one; 8-Chloro-6-fluoro-3,4-dihydro-2H-1-benzopyran-4-one; Chroman-4-one, 8-chloro-6-fluoro-
EINECS	Contact for details

Quality Control

Our 8-Chloro-6-Fluorochroman-4-One is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS), to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.